CBD & Chronic, Non-Cancer Pain: The Harsh Truth

In this video, Matt (Matty) Zielezienski breaks down current research surrounding CBD and chronic, non-cancer pain (CNCP). Recent meta-analyses, risks & benefits, and neurobiological mechanisms of CBD are examined to understand the potential (or lack of ) analgesic effects of this compound. If you found value in this video, please share it with others and subscribe to this channel. I am not a cannabinoid researcher, so the credibility of these claims may be based upon the references below.

***I am not a doctor and this is not to be construed as medical advice.


1. Allan G.M., Finley C.R., Ton J., et al. (2018) Systematic review of systematic reviews for medical cannabinoids: Pain, nausea and vomiting, spasticity, and harms. Can Fam Physician, 64(2), e78‐e94.
2. Blue Ribbon Group. “Best CBD Oil for Pain: Top 5 Brands & Buyer’s Guide.” Discover Magazine, Discover Magazine, 24 Apr. 2020, www.discovermagazine.com/health/best-cbd-oil-for-pain-top-5-brands-and-buyers-guide.
3. Boyaji, S., Merkow, J., Elman, R.N., Kaye, A.D., Yong, R.J., Urman, R.D. (2020). The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence. Current Pain and Headache Reports, 24, 4. https://doi.org/10.1007/s11916-020-0835-4
4. Fitzcharles, M., Baerwald, C., Ablin, J. et al. (2016). Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis). Schmerz, 30, 47–61. https://doi.org/10.1007/s00482-015-0084-3
5. Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European journal of pain (London, England), 20(6), 936–948. https://doi.org/10.1002/ejp.818
6. Harrison J., VanDolah, B.A., Bauer, B.A., & Mauck, K.F. (2019). Clinicians’ Guide to Cannabidiol and Hemp Oils. Mayo Clinic Proceedings, 94(9), 1840-1851. https://doi.org/10.1016/j.mayocp.2019.01.003
7. Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154. https://doi.org/10.1089/can.2016.0034
8. Johal, H., Devji, T., Chang, Y., Simone, J., Vannabouathong, C., Bhandari, M. (2020). Cannabinoids in Chronic Non-Cancer Pain: A Systematic Review and Meta-Analysis. Clinical Medical Insights in Arthritis Musculoskeletal Disorders, 13, 1179544120906461. Published 2020 Feb 19. doi:10.1177/1179544120906461
9. Mackie, K. (2006). Mechanisms of CB1 receptor signaling endocannabinoid modulation of synaptic strength. International Journal of Obesity 30, S19–S23). https://doi.org/10.1038/sj.ijo.0803273
10. Madden, K., van der Hoek, N., Chona, S., George, A., Dalchand, T., Baldawi, H., Mammen,G., Bhandari, M., (2018). Cannabinoids in the management of musculoskeletal pain. JBJS Reviews , 6 (5) , e7 doi: 10.2106/JBJS.RVW.17.00153
11. May S. & Serpell M. (2009). Diagnosis and assessment of neuropathic pain. F1000 Med Rep, 1, 76. doi:10.3410/M1-76
12. McGill Pain Questionnaire. (2017, November 3). Physiopedia. Retrieved from https://www.physiopedia.com/index.php?title=McGill_Pain_Questionnaire&oldid=180325.
13. Mouraux A. & Iannetti GD. (2018). The search for pain biomarkers in the human brain. Brain, 141(12), 3290‐3307. doi:10.1093/brain/awy281
14. Notcutt, W., Price, M., Miller, R., Newport, S., Phillips, C., Simmons, S., Sansom, C. (2004). Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 ‘N of 1’ studies. Anaesthesia, 59(5), 440‐452. doi:10.1111/j.136-2044.2004.03674.x
15. Numeric Pain Rating Scale. (2020, May 13). Physiopedia, . Retrieved 16:16, May 14, 2020 from https://www.physio-pedia.com/index.php?title=Numeric_Pain_Rating_Scale&oldid=237589
16. Raja, S. Carr, D. , Cohen, M., Finnerup, N., Flor, H., Gibson, S., Keefe, F.,  Mogil, J., Ringkamp, M., Sluka, K., Song, X. J., Stevens, B., Sullivan, M. D., & Ushida, T. (2019). IASP’s Proposed New Definition of Pain Released for Comment. IASP. https://www.iasppain.org/PublicationsNews/NewsDetail.aspxItemNumber=9218
17. Stannard, C., & Moore, A. (2016). Traditional opioids for chronic non-cancer pain: untidy, unsatisfactory, and probably unsuitable. Retrieved from https://uk.cochrane.org/news/traditional-opioids-chronic-non-cancer-pain-untidy-unsatisfactory-and-probably-unsuitable
18. Stockings, E., Campbell, G., Hall, W., Nielsen, S., Zagic, D., Rahman, R., Murnion, B., Farrell, M., Weier, M., Degenhardt, L. (2018). Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies. PAIN, 159 (10), 1932-1954. doi: 10.1097/j.pain.0000000000001293

***Reached limit. Remaining references found in slides at the end of the presentation


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